当前位置: 首页 > >

对乙酰氨基酚在n-丁基吡啶六氟磷酸盐修饰碳糊电极上的灵敏测定

发布时间:

第24卷第3期 201 纺织高校基础科学学报 BASIC SCIENCES JOURNAL OF TEXTILE UNIVERSITIES V01.24,N0.3 Sept..201 1 1年9月 Article ID:1006-8341(2011)03-0406-07 Sensitive voltammetric determination of paracetamol based on ionic liquid n-butyl pyridinium hexafluo— phosphate modified carbon paste electrode LOU Guang-xin,ZHANG Jian-fu,SHANGGUAN Xiao—dong, XIAO Xue—hong,DANG Shao—li (Baoji V∞a6伽l Technology Colhge,Baoji,Shaanxl 721013,China) by mixing hydrophobic IDOl graphite acetate Abstract:A carbon ionic liquid electrode(cmv.),which Was fabricated temperature ionic liquid,,l—butyl pyridinium der,W88 used to hexafluophosphate([SuPy][PF6]),with wave pew- buffer investigate the electrochemical behaviors of paracetamol in 0.1 mol/L cyclic solution(pH 4.7)by etry.1he voltammew/(cv),square voltammetry(swv)and chronocoulom— scan peak—to-peak potential separation(△岛)of paracetamol was 0.088 V with rate of 0.1 V/8.The results showed that CILE exhibited better electrocatalysis for redox of paracetam01.Diffu. sion coefficient(D)Was calculated∞1.214×10~cm2/s.The at oxidation peak current versus concen. tration of paraeetamol ClLE showed linearity in the range of O.5-10.0 ttmol/L proposed method WaS r=O.998 to 8)with a detection limit of 0.01 ttmot/L(S/N=3).弧e appued determination of paracetamol in tablets and urine samples successfully.In addition,CILE Was peatable and easy to be fabricated. inexpensive,stable,re- Key words:voltamme缸y;electrocatalysis;carbon ionic liquid electrode;paracetamol CLC mumber:O 651 Document code:A 0 Introduction Paracetamol(i.e.n-acetyl-paminophenol,4-acetamidophenol or acetaminophen)is an acylated aromatic amide.which has been used∞a very effective treatment for the relief of fever and moderate paint 11.At normal therapeutic doses,paracetamol is metabolisecl very fast and completely by undergoing glucuronidafion and sulpha- are tion to inactive metabolites that Many methods eliminated in the urme. were utilized for determination of paraeetamol,alone and ilrl mixtures.in formulations and a8 bi. ological samples,such spectrophotometry,electro-analytical methods,liquid chromatography。capillary dec- trophoretic methods,water analysis and Received date:2011-01.15 titrimetry[圳.Both titrimetry and specu-ophotometry methods involve a Foundation item:Suppoaed by the Science Foundation《Baoji Biography:SHANGGUANXiao-dons(1970-),male,anative ji Vocational Technology 0f蜊aI-g Vocational Technology College(20100



友情链接: